.png){kind=logo}
01The word
They ask about Q3 and the word arrives in the same second the question lands. Budget. Where it used to live, on time. Nobody at the table notices — you’re the only one who needed to.
Founding cohortNow enrolling
Your discipline didn’t fail.The rules changed.
A physician-directed practice for the whole picture — hormones, metabolism, labs, and the questions you’d otherwise be answering for yourself at 11pm.
Start the screening
4 min · Prescribed only when rightTakes about 4 minutes · Prescribed only when clinically right
The 24-week protocol
- Duration
- 24 weeks
- Structure
- 4 chapters
- Direction
- Physician-directed
You’re seen
Your labs came back “normal.”You didn’t.
In perimenopause, nine biological events can be underway that a five-marker annual panel was never built to see. We treat what you live — the page never decides whether you’re believed.
- 01
Estrogen withdraws.
Ovarian E2 decline — cycle chaos, symptom cascade
- 02
Muscle synthesis resists.
Anabolic resistance — strength loss, stiff joints, frozen shoulder
- 03
Insulin response narrows.
Metabolic shift — visceral fat gain, midsection thickens
- 04
Cortisol inverts.
HPA dysregulation — wired-tired, 3 AM wakes, flat mornings
- 05
Sleep fractures.
Slow-wave collapse — broken nights, unrefreshed, night-sweat wakes
- 06
Thermostat misfires.
Hypothalamic thermoregulation — hot flashes, night sweats, flushing
- 07
Appetite deregulates.
Reward + leptin signaling — food noise, cravings, late-day hunger
- 08
Neural circuits fray.
E2-modulated CNS — brain fog, word gaps, anxiety, mood surges
- 09
Bone thins.
BMD loss 1–2% / year — silent until fracture, postural drift
“Nine systems shifting at once — while every tool you’d been handed was built for one.”
The clinical reality4 fronts
Why effort stopped producing response.
01The tools
Every fix was built for one system.
A diet for the body. An app for the sleep. An antidepressant for the mood. Physical therapy for the shoulder. Nine systems shifted together — and every tool you were handed was aimed at exactly one.
02The effort
Discipline stopped compounding.
At 35, eating less and moving more produced response within weeks. In perimenopause the same inputs return smaller, slower outputs — and willpower can't out-negotiate a brain on shifting estrogen and rising cortisol.
03The visibility
Standard labs missed it.
The five-marker panel your GP runs at your annual physical isn't designed to surface what changed. Your numbers come back normal while you don't feel normal.
04The care
Each specialist saw one slice.
The orthopedist saw a shoulder. The therapist heard the mood. The GP read the panel. Each was right about their slice — and no one was reading nine events as one picture.
It was never nine separate problems. It is one shift — and it takes one practice, treating the whole of it, to turn it around.
If most of this sounds like you, the 4-minute screening is the next step.
Start the screening
Takes about 4 minutes.
The return 3 scenes
Three returned moments No before, no after — just back
02Three o’clock
Three o’clock is just three o’clock. You finish the deck, answer the email, take the call. The wall isn’t there — and it wasn’t there yesterday either.
03The Wednesday jeans
The jeans you kept for the version of you that you weren’t sure was coming back. You wore them on a Wednesday. Nothing about the day was about them.
None of these are transformations. They are the things you used to do without thinking — back where they used to be.
If one of those scenes is the one you’re missing — the screening is where it starts.
Start the screening
Takes about 4 minutes.
The standard4 anchors
CertifiedLegitScript healthcare
Weightstry is LegitScript-certified. Verify
Clinicians
Trained in obesity medicine.
Every member is matched with a clinician and a registered dietitian.
Matched by license, specialty, and clinical fit — not by who is free.
Labs
Quest and Labcorp panels.
Lipids, hormones, metabolic and inflammatory markers drawn at intake.
Re-drawn at week 12 and week 24. Tracked, not assumed.
Pharmacy
Named on every shipment.
State-licensed U.S. compounding pharmacy dispenses every prescription.
Active ingredient, lot, and pharmacy named on the Transparency Card.
Review
Every protocol, reviewed.
No volume targets.
No five-minute consults.
Every protocol clinician-reviewed before dispense.
The medication
Three HRT formulations and two GLP-1 protocols. Your clinician matches what your biology actually needs — estradiol patch, micronized progesterone, testosterone cream, semaglutide, tirzepatide — dosed to your symptoms and stage, with labs at baseline and month three keeping it safe. Each prescription is compounded by a 503A pharmacy, labeled with your name and lot number, and ships with a Transparency Card.
Bioidentical hormones
Estradiol patch, progesterone capsule, optional testosterone cream. Sequenced to your stage.
Compounded GLP-1
Semaglutide or tirzepatide. Matched at baseline, escalated by response.
Our clinical team
Every Weightstry member is matched with an obesity medicine clinician and a registered dietitian. We don’t list our clinicians publicly. They’re matched to you when you screen — by license, specialty, and clinical fit.
Medical oversight
Dr. Sergio Naccarato, MD
Medical Director · Board-certified, Emergency Medicine
Dr. Naccarato holds clinical oversight of the practice: appropriate prescribing, physician-guided protocols, and care that treats metabolic and hormonal health as the connected systems they are.
The science
Read the references
“In the STEP-1 trial22, participants on semaglutide achieved an average of 0.0% body weight loss at 68 weeks. In SURMOUNT-123, participants on tirzepatide achieved 0.0% at 72 weeks.”
Read the references